Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235050 | 0.95 | POLB (0.38) | POLBGABRPGABRDGABRA1TSHR | |
| Bicarbonate SCHEMBL9239312 | 0.87 | HTT (0.49) | POLBTSHRMAPK1HTTLMNA | |
| Bicarbonate SCHEMBL9233396 | 0.86 | HTT (0.48) | POLBTSHRMAPK1HTTLMNA | |
| SCHEMBL9234908 | 0.85 | POLB (0.42) | POLBTSHRMAPK1HTTLMNA | |
| SCHEMBL9236118 | 0.84 | ITGB3 (0.45) | POLBGABRPGABRDGABRA1TSHR | |
| Bicarbonate SCHEMBL9235058 | 0.82 | HTT (0.49) | POLBTSHRMAPK1HTTLMNA | |
| SCHEMBL9232196 | 0.77 | POLB (0.35) | POLBTSHRITGB3ITGA2BF2R | |
| SCHEMBL9232195 | 0.77 | POLB (0.35) | POLBTSHRITGB3ITGA2BF2R | |
| SCHEMBL9237755 | 0.77 | SMN1; SMN2 (0.60) | TSHRHTTTPSAB1TPSD1TPSG1 | |
| SCHEMBL9237279 | 0.75 | DRD2 (0.43) | POLBGABRPGABRDGABRA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | claimed |
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |