SCHEMBL9655522

SCHEMBL9655522

COC(=O)C1=C(Cl)C(=O)C(C(=O)OC)=C(Cl)C1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 4/20 0.39
FGFR2 P21802 4/20 0.39
FGFR4 P22455 4/20 0.39
FGFR3 P22607 4/20 0.39
SRC P12931 3/20 0.39
NPSR1 Q6W5P4 2/20 0.39
CDC25A P30304 1/20 0.38
CDC25B P30305 1/20 0.38
ALDH1A1 P00352 5/20 0.35
TSHR P16473 2/20 0.34
MAPT P10636 4/20 0.34
KDM4E B2RXH2 2/20 0.34
LMNA P02545 1/20 0.34
PKM P14618 1/20 0.34
MAPK1 P28482 1/20 0.34
CCR6 P51684 1/20 0.34
MCL1 Q07820 1/20 0.34
ATM Q13315 1/20 0.34
APOBEC3G Q9HC16 1/20 0.34
ABL1 P00519 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9242569 0.78 NPSR1 (0.46) FGFR1FGFR2FGFR4FGFR3SRC
SCHEMBL21234787 0.70 FGFR1 (0.39) FGFR1FGFR2FGFR4FGFR3SRC
SCHEMBL9063074 0.67 NPSR1 (0.46) NPSR1ALDH1A1TSHRMAPTKDM4E
Dacthal SCHEMBL8827292 0.65 CA12 (0.48) NPSR1ALDH1A1TSHRMAPTKDM4E
Dacthal SCHEMBL53477 0.65 CA12 (0.48) NPSR1ALDH1A1TSHRMAPTKDM4E
SCHEMBL10894094 0.65 FGFR1 (0.37) FGFR1FGFR2FGFR4FGFR3SRC
SCHEMBL5334826 0.63 CA12 (0.46) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL8339188 0.63 CA12 (0.46) NPSR1ALDH1A1TSHRMAPTKDM4E
SCHEMBL21416095 0.63 SLC6A3 (0.33) FGFR1FGFR2FGFR4FGFR3SRC
SCHEMBL10260335 0.62 CA1 (0.57) NPSR1ALDH1A1TSHRMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3521378-B1 PYRIMIDOQUINAZOLINE PIGMENT, METHOD FOR MANUFACTURING PYRIMIDOQUINAZOLINE PIGMENT, AND PIGMENT COLORANT DAINICHISEIKA COLOR CHEM (JP) 2022-07-06 EP disclosed
US-11021441-B2 High solubility thioether quinones WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-06-01 US disclosed
US-20200223794-A1 High Solubility Thioether Quinones WISCONSIN ALUMNI RESEARCH FOUNDATION 2020-07-16 US disclosed
US-10655017-B2 Pyrimidoquinazoline pigment, method for manufacturing pyrimidoquinazoline pigment, and pigment colorant DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) 2020-05-19 US disclosed
EP-3521378-A1 PYRIMIDOQUINAZOLINE PIGMENT, METHOD FOR MANUFACTURING PYRIMIDOQUINAZOLINE PIGMENT, AND PIGMENT COLORANT Dainichiseika Color & Chemicals Mfg. Co., Ltd. (JP) 2019-08-07 EP disclosed
US-20190233649-A1 PYRIMIDOQUINAZOLINE PIGMENT, METHOD FOR MANUFACTURING PYRIMIDOQUINAZOLINE PIGMENT, AND PIGMENT COLORANT DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) 2019-08-01 US disclosed
US-20190055193-A1 High-Solubility Thioether Quinones U.S. DEPARTMENT OF ENERGY 2019-02-21 US disclosed
EP-0355492-B1 REACTIVE DYES BAYER AG (DE) 1992-12-09 EP disclosed
US-5138054-A Colorfastness, photostability; red dye BAYER AKTIENGESELLSCHAFT (DE) 1992-08-11 US disclosed
US-5130291-A HEAT-SENSITIVE RECORDING PAPER OSAKA SEALING PRINTING CO., LTD. (JP) 1992-07-14 US disclosed
EP-0355492-A1 Reactive dyes BAYER AG (DE) 1990-02-28 EP disclosed
EP-0133182-B1 OXIDATION-REDUCTION COLOR PRODUCTION-TYPE HEAT-SENSITIVE RECORDING UNIT MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-03-15 EP disclosed
EP-0055847-B1 PRESSURE SENSITIVE RECORDING UNIT MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-04-02 EP disclosed
US-4561000-A METHINE-TYPE CHROMOGEN, BENZOQUINONE OXIDIZER, COLOR PRODUCTION SENSITIVITY REGULATOR, SUBSTRATE MITSUI TOATSU CHEMICALS, INC. (JP) 1985-12-24 US disclosed
EP-0133182-A1 OXIDATION-REDUCTION COLOR PRODUCTION-TYPE HEAT-SENSITIVE RECORDING UNIT MITSUI TOATSU CHEMICALS, Inc. (JP) 1985-02-20 EP disclosed
US-4398753-A METHINE-TYPE DYES AND QUINONE DERIVATIVE IN REDOX SYSTEM FOR CARBON-FREE REPRODUCTION MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1983-08-16 US disclosed
EP-0055847-A1 Pressure sensitive recording unit MITSUI TOATSU CHEMICALS, Inc. (JP) 1982-07-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11021441-B2 High solubility thioether quinones SQOR, TST, NDUFS3 FGFR1 1182/4885FGFR2 1139/4885FGFR4 1527/4885
US-20200223794-A1 High Solubility Thioether Quinones SQOR, TST, NDUFS3 FGFR1 1182/4885FGFR2 1139/4885FGFR4 1527/4885
US-20190055193-A1 High-Solubility Thioether Quinones SQOR, TST, NDUFS3 FGFR1 1200/4885FGFR2 1236/4885FGFR4 1721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.