Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252834 | 1.00 | MAOB (0.45) | MAOBMAOACCR2CHRNA1CHRNG | |
| SCHEMBL9249020 | 1.00 | MAOB (0.45) | MAOBMAOACCR2CHRNA1CHRNG | |
| SCHEMBL25583946 | 0.81 | MAOB (0.47) | MAOBMAOACCR2CHRNA1CHRNG | |
| SCHEMBL9393623 | 0.80 | HSD11B1 (0.39) | MAOBMAOACCR2CHRNA1CHRNG | |
| SCHEMBL20177097 | 0.79 | TAAR1 (0.40) | HSD11B1ALDH1A1 | |
| SCHEMBL13953489 | 0.78 | SLC18A3 (0.41) | MAOBMAOACCR2CHRNB2SLC6A2 | |
| SCHEMBL8240067 | 0.75 | MAOB (0.45) | MAOBMAOACCR2HSD11B1POLB | |
| SCHEMBL9230998 | 0.75 | MAOB (0.43) | MAOBMAOACCR2CHRNA1CHRNG | |
| SCHEMBL13932847 | 0.75 | MAOB (0.41) | MAOBMAOACCR2CHRNA1CHRNG | |
| SCHEMBL13361601 | 0.71 | SLC6A3 (0.48) | MAOBMAOACHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048227-A1 | Substituted-1-Phthalazinamines As Vr- 1 Antagonists | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| EP-0636119-A1 | PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021149-A1 | PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1993-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048227-A1 | Substituted-1-Phthalazinamines As Vr- 1 Antagonists | TRPV1, TRPV2, TRPV5 | MAOB 3114/4885MAOA 1961/4885CCR2 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.