Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 4-Methoxycinnamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | XDH | P47989 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Methoxycinnamic Acid SCHEMBL9249235 | 1.00 | MAPT (0.58) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| 4-Methoxycinnamic Acid SCHEMBL9249233 | 0.90 | MAPT (0.52) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| 4-Methoxycinnamic Acid SCHEMBL5758098 | 0.89 | MAPT (0.72) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| Cinnamic Acid SCHEMBL6742986 | 0.79 | CYP1B1 (0.70) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| Cinnamic Acid SCHEMBL9102682 | 0.79 | CYP1B1 (0.70) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| 4-Methoxycinnamic Acid SCHEMBL28105146 | 0.78 | THRB (0.89) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| Aminobenzoic Acid SCHEMBL28077463 | 0.77 | ALDH1A1 (0.67) | MAPTCYP2C9CYP2C19THRBLMNA | |
| Ferulate SCHEMBL8056989 | 0.76 | KDM4E (0.77) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| SCHEMBL2807599 | 0.74 | MAPT (1.00) | MAPTMAOBMAOACYP2D6CYP2C9 | |
| SCHEMBL2807601 | 0.74 | MAPT (1.00) | MAPTMAOBMAOACYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004519-A1 | POORLY WATER-SOLUBLE SALTS OF SUNSCREEN AGENTS | UNILEVER PLC (GB) | 1995-02-16 | — | — | WO | claimed |
| WO-1995004519-A1 | POORLY WATER-SOLUBLE SALTS OF SUNSCREEN AGENTS | UNILEVER PLC (GB) | 1995-02-16 | — | — | WO | disclosed |