Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.43 |
| ▸ | PRNP | P04156 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | PTGFR | P43088 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24150723 | 0.83 | CA12 (0.49) | ALDH1A1HTTL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL9736420 | 0.82 | NCEH1 (0.46) | ALDH1A1HTTL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL11507377 | 0.79 | POLB (0.56) | ALDH1A1L3MBTL1SMN1; SMN2LMNAPOLB | |
| SCHEMBL27619794 | 0.76 | CA12 (0.50) | ALDH1A1HTTL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL19328740 | 0.75 | PTGFR (0.62) | ALDH1A1HTTMEN1KMT2ARXFP1 | |
| SCHEMBL9039455 | 0.73 | CYP3A4 (0.55) | ALDH1A1HTTL3MBTL1LMNAPOLB | |
| SCHEMBL18481324 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL358180 | 0.72 | KDM4E (0.70) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL8346118 | 0.71 | ALDH1A1 (0.41) | ALDH1A1HTTL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL6828042 | 0.71 | MEN1 (0.48) | ALDH1A1L3MBTL1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426189-A | Dopamine receptor ligands and imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1995-06-20 | — | — | US | disclosed |
| US-5334728-A | Dopamine receptor ligands and imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1994-08-02 | — | — | US | disclosed |
| US-5186921-A | 3-methoxy-n(1-ethyl-2-pyrrolidinyl)methyl)naphthyl-2-carboxy amide compounds for imaging human brains; good retention stability | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1993-02-16 | — | — | US | disclosed |
| US-5122361-A | 2-Pyrrolidinylmethylcarboxamido-2,3-dihydrobenzofuran type compounds | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0393838-A1 | Dopamine receptor ligands and imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1990-10-24 | — | — | EP | disclosed |