Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MDH2 | P40926 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9254180 | 0.87 | CTSV (0.52) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL30935740 | 0.74 | KMT2A (1.00) | KMT2AMEN1ALDH1A1THRBNPC1 | |
| SCHEMBL9446270 | 0.74 | KMT2A (0.56) | KMT2AMEN1ALDH1A1THRBNPC1 | |
| SCHEMBL9254946 | 0.72 | GLA (0.45) | KMT2AALDH1A1RAB9AHPGDRXFP1 | |
| SCHEMBL9258760 | 0.70 | CYP19A1 (0.39) | RAB9ACYP1A2 | |
| SCHEMBL31507105 | 0.70 | TP53 (0.50) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL27040438 | 0.70 | TP53 (0.50) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL9247982 | 0.70 | CTSV (0.47) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL9251528 | 0.68 | CTSV (0.46) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL6295907 | 0.67 | ALDH1A1 (0.81) | KMT2AMEN1ALDH1A1THRBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393756-A | Treating rheumatoid arthritis or osteoarthritis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-02-28 | — | — | US | disclosed |
| US-5225418-A | Arthritis | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-07-06 | — | — | US | disclosed |