Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FABP7 | O15540 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446385 | 0.83 | RXRA (0.47) | RXRARXRBRXRGCES2CES1 | |
| SCHEMBL7795580 | 0.82 | PTGS2 (0.48) | RXRARXRBRXRGCES2CES1 | |
| SCHEMBL8469587 | 0.82 | RXRA (0.42) | RXRARXRBRXRGDRD1CES2 | |
| SCHEMBL6950322 | 0.79 | KDM4E (0.46) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL28731478 | 0.79 | ALOX15 (0.42) | RXRARXRBRXRGCES2CES1 | |
| SCHEMBL28731487 | 0.78 | ALOX15 (0.44) | RXRARXRBRXRGDRD1DRD2 | |
| SCHEMBL28731739 | 0.77 | ALOX15 (0.45) | RXRARXRBRXRGDRD1DRD2 | |
| SCHEMBL28731467 | 0.77 | ALOX15 (0.46) | RXRARXRBRXRGCES2CES1 | |
| SCHEMBL9571254 | 0.76 | RXRA (0.47) | RXRARXRBRXRGCES2CES1 | |
| SCHEMBL6448663 | 0.76 | SLC13A5 (0.39) | RXRARXRBRXRGDRD1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |