Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446385 | 0.86 | RXRA (0.47) | KDM4ELMNATSHRALDH1A1TDP1 | |
| SCHEMBL28731478 | 0.85 | ALOX15 (0.42) | KDM4ELMNAALDH1A1RXRARXRB | |
| SCHEMBL6950322 | 0.85 | KDM4E (0.46) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL8469587 | 0.84 | RXRA (0.42) | KDM4ELMNATSHRALDH1A1TDP1 | |
| SCHEMBL28731487 | 0.84 | ALOX15 (0.44) | KDM4ELMNAALDH1A1RXRARXRB | |
| SCHEMBL28731467 | 0.82 | ALOX15 (0.46) | KDM4ELMNAALDH1A1RXRARXRB | |
| SCHEMBL28731739 | 0.82 | ALOX15 (0.45) | KDM4ELMNARXRARXRBRXRG | |
| SCHEMBL9250596 | 0.82 | RXRA (0.40) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL27489237 | 0.82 | BACE1 (0.51) | PTGS2KDM4EHSD17B10LMNACYP1A2 | |
| SCHEMBL28703480 | 0.82 | PTGS2 (0.52) | PTGS2KDM4EHSD17B10LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103382154-B | Synthetic method of methyl 4'-bromomethylbiphenyl-2-carboxylate | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2015-01-21 | — | — | CN | claimed |
| CN-103382154-A | Synthetic method of methyl 4'-bromomethylbiphenyl-2-carboxylate | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2013-11-06 | — | — | CN | claimed |
| CN-114436833-A | Preparation method of telmisartan key intermediate 4' -methylbiphenyl-2-carboxylic ester | 南京红太阳医药研究院有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-103382154-B | Synthetic method of methyl 4'-bromomethylbiphenyl-2-carboxylate | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2015-01-21 | — | — | CN | disclosed |
| CN-103382154-A | Synthetic method of methyl 4'-bromomethylbiphenyl-2-carboxylate | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2013-11-06 | — | — | CN | disclosed |
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5283241-A | Animal growth regulators | MERCK & CO., INC. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |