Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | BRD1 | O95696 | 2/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.44 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31018134 | 0.81 | ALDH1A1 (0.53) | BRPF1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21977872 | 0.81 | ALDH1A1 (0.53) | BRPF1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11467250 | 0.79 | BRPF1 (0.65) | BRPF1KDM4EALDH1A1BRD4BRD1 | |
| SCHEMBL31202639 | 0.79 | BRPF1 (0.65) | BRPF1KDM4EALDH1A1HPGDBRD4 | |
| SCHEMBL14721985 | 0.79 | BRPF1 (1.00) | BRPF1KDM4EALDH1A1HPGDBRD4 | |
| SCHEMBL15970406 | 0.78 | ALDH1A1 (0.50) | BRPF1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8040679 | 0.77 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9256256 | 0.77 | KDM4E (0.49) | BRPF1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30249048 | 0.77 | ALDH1A1 (0.49) | BRPF1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31202587 | 0.76 | BRPF1 (0.61) | BRPF1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |
| EP-0381375-A1 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-08 | — | — | EP | disclosed |