Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21977872 | 0.79 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDHSD17B10BRPF1 | |
| SCHEMBL9209958 | 0.79 | DAO (0.57) | KDM4EHSD17B10BRPF1KMT2AAHR | |
| SCHEMBL31018134 | 0.79 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDHSD17B10BRPF1 | |
| SCHEMBL9250818 | 0.77 | BRPF1 (0.65) | KDM4EALDH1A1HPGDHSD17B10BRPF1 | |
| SCHEMBL15970406 | 0.73 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDHSD17B10BRPF1 | |
| SCHEMBL30249048 | 0.72 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDHSD17B10BRPF1 | |
| SCHEMBL15565909 | 0.72 | THRB (0.42) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9257087 | 0.69 | BRPF1 (0.62) | KDM4EALDH1A1HPGDHSD17B10BRPF1 | |
| SCHEMBL8040679 | 0.69 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL11965203 | 0.68 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5283245-A | Antiinflammatory agent, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-01 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |