Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260626 | 0.93 | KDM4E (0.51) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL9255557 | 0.91 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL27350858 | 0.91 | OPRM1 (0.48) | OPRM1EGFRCDK2SIGMAR1KMT2A | |
| SCHEMBL27439205 | 0.84 | OPRM1 (0.48) | OPRM1SIGMAR1KMT2ACHRM3OPRD1 | |
| SCHEMBL9260006 | 0.84 | CNR1 (0.53) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL9251803 | 0.83 | ACHE (0.50) | KDM4EALDH1A1HPGDOPRM1ACHE | |
| SCHEMBL9264547 | 0.80 | SLC6A2 (0.47) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL9254627 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1OPRM1ACHESIGMAR1 | |
| SCHEMBL9261885 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1OPRM1ACHESIGMAR1 | |
| SCHEMBL9251113 | 0.78 | ACHE (0.54) | KDM4EALDH1A1HPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |