Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | FPR1 | P21462 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265216 | 0.92 | ALDH1A1 (0.53) | ACHEMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL27398872 | 0.92 | OPRM1 (0.52) | KDM4EALDH1A1GPR17KMT2AMEN1 | |
| SCHEMBL9260626 | 0.89 | KDM4E (0.51) | ACHEKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9251106 | 0.83 | KDM4E (0.51) | ACHEKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL27439205 | 0.80 | OPRM1 (0.48) | MAOAMAOBKMT2ACHRM3SIGMAR1 | |
| SCHEMBL9251812 | 0.79 | ACHE (0.64) | ACHEMAOAMAOBBCHE | |
| SCHEMBL9255557 | 0.77 | ALDH1A1 (0.50) | ACHEMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL9260006 | 0.76 | CNR1 (0.53) | ACHEMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL27350858 | 0.75 | OPRM1 (0.48) | MAOAMAOBKMT2ACHRM3SIGMAR1 | |
| SCHEMBL9261885 | 0.73 | KDM4E (0.51) | ACHEKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |