Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MDH1 | P40925 | 1/20 | 0.43 |
| ▸ | MDH2 | P40926 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9257649 | 0.89 | RXRA (0.52) | HDAC6NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9258477 | 0.86 | MAPT (0.46) | HDAC6NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9263275 | 0.85 | NPC1 (0.48) | HDAC6NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9262771 | 0.84 | MAPT (0.51) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9256474 | 0.83 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9260302 | 0.82 | NPC1 (0.48) | HDAC6NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9252898 | 0.80 | HDAC6 (0.57) | HDAC6NPC1RAB9AMAPTPOLB | |
| SCHEMBL9260521 | 0.80 | HDAC6 (0.48) | HDAC6NPC1RAB9AMAPTLMNA | |
| SCHEMBL9261977 | 0.76 | HDAC6 (0.46) | HDAC6NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9260470 | 0.75 | HDAC6 (0.44) | HDAC6NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432195-A | Anticholesterol | NIPPON SHINYAKU COMPANY LIMITED (JP) | 1995-07-11 | — | — | US | disclosed |
| EP-0601181-A1 | BENZOFURAN DERIVATIVE AND PHARMACEUTICAL COMPOSITION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1994-06-15 | — | — | EP | disclosed |