Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | NCK1 | P16333 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13298989 | 0.83 | CYP1A2 (0.52) | CYP1A2BACE1NCK1PSMB5ALDH1A1 | |
| SCHEMBL9255457 | 0.81 | CYP1A2 (0.49) | CYP1A2MAOBMAOABACE1NCK1 | |
| SCHEMBL14269740 | 0.81 | MBNL1 (0.50) | CYP1A2BACE1NCK1PSMB5ALDH1A1 | |
| SCHEMBL18944032 | 0.79 | ALDH1A1 (0.48) | CYP1A2MAOBMAOABACE1NCK1 | |
| SCHEMBL28063766 | 0.79 | RAB9A (0.50) | CYP1A2ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30462939 | 0.79 | RAB9A (0.50) | CYP1A2ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23247265 | 0.78 | CYP1A2 (0.68) | CYP1A2BACE1NCK1PSMB5ALDH1A1 | |
| SCHEMBL13298987 | 0.77 | CYP1A2 (0.49) | CYP1A2BACE1NCK1PSMB5ALDH1A1 | |
| SCHEMBL8482877 | 0.77 | KDM4E (0.47) | CYP1A2BACE1NCK1PSMB5ALDH1A1 | |
| SCHEMBL13298969 | 0.76 | CYP1A2 (0.55) | CYP1A2MAOBMAOABACE1NCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457112-A | Glaucoma, hypotensive agents | SYNTHELABO (FR) | 1995-10-10 | — | — | US | disclosed |
| EP-0540400-B1 | Quinoline derivatives, useful as angiotensin II antagonists | SYNTHELABO (FR) | 1995-08-23 | — | — | EP | disclosed |
| US-5432283-A | Substituted phenyl in 2 position; intermediates for drugs to treat hypertensive pathologies, cardiac, renal or pulmonary insufficiencies, and glaucoma | SYNTHELABO (FR) | 1995-07-11 | — | — | US | disclosed |
| US-5371227-A | Quinoline derivatives, process for their preparation, and their therapeutic applications | SYNTHELABO (FR) | 1994-12-06 | — | — | US | disclosed |
| EP-0604259-A1 | 3-(Quinolin-6-yl-methyl)-4H-imidazol-4-one derivatives as angiotensin II antagonists | SYNTHELABO (FR) | 1994-06-29 | — | — | EP | disclosed |
| EP-0540400-A1 | Quinoline derivatives, useful as angiotensin II antagonists | SYNTHELABO (FR) | 1993-05-05 | — | — | EP | disclosed |