Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | GRK6 | P43250 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27043019 | 0.85 | ALOX5 (0.59) | TNKS2MAPTALDH1A1ALOX5 | |
| SCHEMBL9715238 | 0.84 | GRM8 (0.39) | RAB9AGRM8GRM4TNKS2MAPT | |
| SCHEMBL9715251 | 0.84 | GRM8 (0.39) | RAB9AGRM8GRM4TNKS2MAPT | |
| SCHEMBL10751886 | 0.83 | RAB9A (0.53) | RAB9AGRM8GRM4TNKS2MAPT | |
| SCHEMBL11158875 | 0.82 | RAB9A (0.55) | RAB9AGRM8GRM4MAPTKDM4E | |
| SCHEMBL7278917 | 0.82 | TTR (0.46) | MAPTKDM4EALDH1A1TTR | |
| SCHEMBL7414973 | 0.80 | IMPDH2 (0.40) | GRM8GRM4MAPTALDH1A1JUN | |
| SCHEMBL7408115 | 0.79 | IMPDH2 (0.39) | MAPTJUNALOX5TTRGRK6 | |
| SCHEMBL7031564 | 0.79 | RAB9A (0.60) | RAB9AGRM8GRM4MAPTKDM4E | |
| SCHEMBL8297049 | 0.78 | RAB9A (0.59) | RAB9AGRM8GRM4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446194-A | Pharmacologically active catechol derivatives | ORION-YHTYMA OY (FI) | 1995-08-29 | — | — | US | disclosed |
| US-5283352-A | Transferase inhibitor | ORION-YHTYMA OY (FI) | 1994-02-01 | — | — | US | disclosed |
| US-5112861-A | Inhibitors of catechol-methyl-transferase enzyme, levodopa | ORION-YHTYMA OY (FI) | 1992-05-12 | — | — | US | disclosed |
| US-4963590-A | ENZYME INHIBITOR FOR TREATING PARKINSON'S DISEASE ALONG WITH DOPA;POTENTIATION | ORION-YHTYMA OY (FI) | 1990-10-16 | — | — | US | disclosed |