Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414973 | 0.99 | IMPDH2 (0.40) | IMPDH2JUNGRK6MAPTGAA | |
| SCHEMBL7412241 | 0.95 | IMPDH2 (0.41) | IMPDH2JUNGRK6MAPTGAA | |
| SCHEMBL7410980 | 0.90 | JUN (0.41) | IMPDH2JUNGRK6MAPTPKM | |
| SCHEMBL7416057 | 0.84 | MAPT (0.40) | IMPDH2MAPTTTRLMNAMAPK1 | |
| SCHEMBL7422136 | 0.82 | MEN1 (0.38) | IMPDH2MAPTTTRLMNAMAPK1 | |
| SCHEMBL7414964 | 0.80 | MAPT (0.43) | IMPDH2JUNGRK6MAPTGAA | |
| SCHEMBL9252028 | 0.79 | RAB9A (0.50) | ALOX5JUNGRK6MAPTTTR | |
| SCHEMBL7415175 | 0.79 | CTSD (0.53) | LMNAHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7420295 | 0.78 | HPGD (0.38) | IMPDH2MAPTTTRLMNAMAPK1 | |
| SCHEMBL7410818 | 0.78 | CTSD (0.45) | IMPDH2ALOX5LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150412-A | SUCH AS 4-(5-HYDROXY-4-METHOXY-2-NITROPHENYL)BUTANOIC ACID; ADMINISTERING TO INHIBIT CATECHOL-O-METHYL TRANSFERASE; TREATING PARKINSON'S DISEASE OR HYPERTENSION | ORION-YHTYMA OY (FI) | 2000-11-21 | — | — | US | disclosed |
| WO-1996037456-A1 | NEW CATECHOL DERIVATIVES | Orion-Yhtymä Oy (FI) | 1996-11-28 | — | — | WO | disclosed |