Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529831 | 0.83 | CHRNB2 (0.41) | ALDH1A3ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL9745966 | 0.79 | ALDH1A1 (0.53) | ALDH1A3ALDH1A1CYP2A6DRD1MAPT | |
| SCHEMBL8550745 | 0.78 | ALDH1A3 (0.57) | ALDH1A3ALDH1A1CYP2A6DRD1MAPT | |
| SCHEMBL11390540 | 0.76 | ALDH1A1 (0.54) | ALDH1A3ALDH1A1CYP2A6DRD1MAPT | |
| SCHEMBL8727778 | 0.76 | ALDH1A3 (0.70) | ALDH1A3ALDH1A1CYP2A6DRD1MAPT | |
| SCHEMBL10359634 | 0.76 | CA4 (0.41) | ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL1915714 | 0.75 | ALDH1A3 (0.58) | ALDH1A3ALDH1A1CYP2A6DRD1MAPT | |
| SCHEMBL11383524 | 0.75 | ALDH1A1 (0.57) | ALDH1A3ALDH1A1CYP2A6MAPTHPGD | |
| SCHEMBL27793483 | 0.75 | KMT2A (0.56) | SMN1; SMN2KMT2ATSHR | |
| SCHEMBL11377574 | 0.73 | ALDH1A1 (0.55) | ALDH1A3ALDH1A1CYP2A6MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5422373-A | An alkoxybenzyl-alkylene-arylurea anticholesterol, antilipemic agents and enzyme inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0550568-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006075-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |