Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | WNT1 | P04628 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9266551 | 0.89 | PLK1 (0.45) | KDM1APLK1PLK2PLK3DYRK1A | |
| SCHEMBL9265566 | 0.88 | HPGDS (0.45) | KDM1APLK1PLK2PLK3DYRK1A | |
| SCHEMBL9259070 | 0.88 | DYRK1A (0.44) | KDM1ADYRK1AGSK3BWNT1AXL | |
| SCHEMBL9262615 | 0.86 | KDM1A (0.42) | KDM1APLK1PLK2PLK3DYRK1A | |
| SCHEMBL15253175 | 0.85 | GPR119 (0.53) | PLK1PLK2PLK3ALDH1A1ACACB | |
| SCHEMBL9261132 | 0.85 | GSK3B (0.41) | KDM1ADYRK1AGSK3BWNT1ALDH1A1 | |
| SCHEMBL15253089 | 0.85 | GPR119 (0.47) | PLK1PLK2PLK3ALDH1A1ACACB | |
| SCHEMBL9250864 | 0.85 | HRH3 (0.46) | KDM1ADYRK1AGSK3BWNT1ALDH1A1 | |
| SCHEMBL9250469 | 0.84 | KDM1A (0.41) | KDM1ADYRK1AGSK3BWNT1ACACB | |
| SCHEMBL8537789 | 0.84 | CHEK2 (0.43) | PLK1PLK2PLK3ACACBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069917-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2012-05-31 | — | — | WO | disclosed |