Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.65 |
| ▸ | BCHE | P06276 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252897 | 0.97 | ACHE (0.67) | ACHEBCHEHTR1ASLC6A4CHRM4 | |
| Fumaric Acid SCHEMBL9249239 | 0.95 | ACHE (0.59) | ACHEBCHEHTR1ASLC6A4CHRM4 | |
| Fumaric Acid SCHEMBL9249220 | 0.95 | ACHE (0.59) | ACHEBCHEHTR1ASLC6A4CHRM4 | |
| SCHEMBL4500124 | 0.92 | ACHE (0.77) | ACHEBCHEHTR1ASLC6A4 | |
| Fumaric Acid SCHEMBL9254343 | 0.92 | ACHE (0.60) | ACHEBCHEHTR1ASLC6A4CHRM4 | |
| Fumaric Acid SCHEMBL9254339 | 0.92 | ACHE (0.60) | ACHEBCHEHTR1ASLC6A4CHRM4 | |
| SCHEMBL9253841 | 0.85 | ACHE (0.70) | ACHEBCHECHRM4 | |
| SCHEMBL9246613 | 0.85 | HTR2A (0.59) | ACHEBCHEHTR2AHTR2CHTR2B | |
| SCHEMBL9253037 | 0.83 | ACHE (0.65) | ACHEBCHEFAAH | |
| SCHEMBL9253116 | 0.82 | ACHE (0.71) | ACHEBCHECHRM4FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441967-A | Treating cerebral edema; anticholinesterase or brain function-improving agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| US-5294625-A | 1-benzyl,4-((4-dialkylaminophenyl)carbonyl)piperidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0378207-B1 | CYCLIC AMINE COMPOUNDS AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-5177087-A | Cerebral edema, cholinesterase inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |