Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10469336 | 0.81 | HSD11B1 (0.48) | HSD11B1SIGMAR1AHRKMT2AMAP3K14 | |
| SCHEMBL7659590 | 0.81 | PPP1CA (0.50) | HSD11B1MAP3K14POLBHTTMAPT | |
| SCHEMBL9259478 | 0.80 | NOTUM (0.50) | HSD11B1KMT2APOLBHTTMAPT | |
| SCHEMBL9265715 | 0.75 | ALDH1A1 (0.55) | HSD11B1AHRKMT2APOLBHTT | |
| SCHEMBL7652843 | 0.72 | NR1H2 (0.50) | HSD11B1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL9196239 | 0.71 | HSD11B1 (0.61) | HSD11B1KMT2AHTTMEN1NPC1 | |
| SCHEMBL11182399 | 0.69 | HSD11B1 (0.43) | HSD11B1SIGMAR1AHRKMT2AMAP3K14 | |
| SCHEMBL22815745 | 0.69 | HSD11B1 (0.60) | HSD11B1SIGMAR1AHRKMT2AKMO | |
| SCHEMBL10563793 | 0.69 | AHR (0.43) | HSD11B1AHRKMT2AHTTMAPT | |
| SCHEMBL2183068 | 0.68 | TDP2 (0.74) | KMT2APOLBHTTMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436252-A | Antiischemic agents, stroke, Alzheimer's or Parkinson's diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-25 | — | — | US | claimed |
| US-5436252-A | Antiischemic agents, stroke, Alzheimer's or Parkinson's diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-25 | — | — | US | disclosed |