Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253485 | 0.80 | HSD11B1 (0.49) | MEN1KMT2ALMNAALDH1A1HTT | |
| SCHEMBL7652843 | 0.80 | NR1H2 (0.50) | KMT2AALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL7306147 | 0.79 | MAPT (0.50) | NOTUMMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3099989 | 0.79 | LMNA (0.49) | NOTUMMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL8235255 | 0.77 | TSHR (0.43) | LMNAALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL9354103 | 0.74 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1HTTKDM4E | |
| SCHEMBL8235862 | 0.72 | TSHR (0.62) | MEN1KMT2ALMNAALDH1A1HTT | |
| SCHEMBL9196239 | 0.72 | HSD11B1 (0.61) | MEN1KMT2ALMNAALDH1A1HTT | |
| SCHEMBL3921034 | 0.72 | KMT2A (0.51) | NOTUMMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL1347557 | 0.68 | ADORA2A (0.73) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436252-A | Antiischemic agents, stroke, Alzheimer's or Parkinson's diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-25 | — | — | US | claimed |
| US-5436252-A | Antiischemic agents, stroke, Alzheimer's or Parkinson's diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-25 | — | — | US | disclosed |
| US-4847276-A | CARDIOVASCULAR DISORDERS | MERRELL DOW PHARMACEUTICALS INC. | 1989-07-11 | — | — | US | disclosed |