Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9254147 | 1.00 | MAPT (0.55) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL9567682 | 0.84 | LMNA (0.51) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL9567685 | 0.84 | LMNA (0.51) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL2812581 | 0.82 | MAPT (0.67) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL10353050 | 0.77 | MAPT (0.57) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL28091426 | 0.77 | MAPT (0.57) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL430650 | 0.74 | NR1H4 (0.50) | SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL6740629 | 0.73 | KMT2A (0.51) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL30973302 | 0.73 | KMT2A (0.51) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL6740625 | 0.73 | KMT2A (0.51) | MAPTLMNANPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430149-A | 5-[(4-bromophenyl)methyl]4-pyrimidinones | SYNTHELABO (FR) | 1995-07-04 | — | — | US | disclosed |
| US-5312920-A | Process for preparing 4-pyrimidinones | SYNTHELABO (FR) | 1994-05-17 | — | — | US | disclosed |