Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.42 |
| ▸ | F10 | P00742 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | PROC | P04070 | 1/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255518 | 0.94 | CHEK2 (0.41) | CHEK2F10HDAC1HDAC8HDAC6 | |
| SCHEMBL9249762 | 0.90 | ITGB3 (0.42) | CHEK2ITGB3ITGA2BF10HDAC1 | |
| SCHEMBL9252912 | 0.86 | ITGB3 (0.43) | CHEK2ITGB3ITGA2BHDAC1HDAC8 | |
| SCHEMBL9252426 | 0.83 | PRSS12 (0.39) | CHEK2ITGB3ITGA2BF10HDAC1 | |
| SCHEMBL9252280 | 0.82 | ITGB3 (0.45) | CHEK2ITGB3ITGA2BF10HDAC1 | |
| SCHEMBL9247795 | 0.81 | ITGB3 (0.44) | CHEK2ITGB3ITGA2BHDAC1HDAC8 | |
| SCHEMBL9254520 | 0.81 | ITGB3 (0.44) | CHEK2ITGB3ITGA2BHDAC1HDAC8 | |
| SCHEMBL9249022 | 0.80 | ITGB3 (0.44) | CHEK2ITGB3ITGA2BHDAC1HDAC8 | |
| SCHEMBL9253344 | 0.80 | JAK2 (0.52) | ITGB3ITGA2BF10HDAC1HDAC8 | |
| SCHEMBL9255533 | 0.80 | NPC1 (0.40) | CHEK2ITGB3ITGA2BHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |