Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484548 | 0.89 | ALDH1A1 (0.50) | ALDH1A1HPGDMEN1KMT2ANOTUM | |
| SCHEMBL22801901 | 0.81 | ALDH1A1 (0.43) | ALDH1A1HPGDMEN1KMT2ANOTUM | |
| SCHEMBL30525520 | 0.76 | HPGD (0.37) | ALDH1A1HPGDMEN1KMT2ANOTUM | |
| SCHEMBL24329594 | 0.76 | SMN1; SMN2 (0.44) | ALDH1A1NOTUMRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL24329970 | 0.76 | HPGD (0.37) | ALDH1A1HPGDMEN1KMT2ANOTUM | |
| SCHEMBL7477785 | 0.74 | LMNA (0.42) | ALDH1A1HPGDMEN1KMT2ARAB9A | |
| SCHEMBL17910548 | 0.73 | ALDH1A1 (0.47) | ALDH1A1HPGDMEN1KMT2ARAB9A | |
| Bromide SCHEMBL8073581 | 0.73 | LMNA (0.41) | ALDH1A1HPGDMEN1KMT2ARAB9A | |
| SCHEMBL22801900 | 0.72 | KMT2A (0.42) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17531765 | 0.72 | MAPT (0.43) | ALDH1A1MEN1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |