Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260014 | 0.93 | CNR1 (0.56) | ACHEBCHEALDH1A1KDM4EHPGD | |
| SCHEMBL9251113 | 0.91 | ACHE (0.54) | ACHEBCHEALDH1A1KDM4EHPGD | |
| SCHEMBL9265225 | 0.86 | ACHE (0.60) | ACHEBCHEALDH1A1KDM4EHPGD | |
| SCHEMBL9260634 | 0.84 | ACHE (0.54) | ACHEBCHEMAOBMAOA | |
| SCHEMBL9255557 | 0.80 | ALDH1A1 (0.50) | ACHEBCHEALDH1A1KDM4EHPGD | |
| SCHEMBL9251812 | 0.77 | ACHE (0.64) | ACHEBCHEMAOBMAOA | |
| SCHEMBL9254634 | 0.75 | MAOB (0.51) | ACHEBCHEMAOBMAOA | |
| SCHEMBL9261890 | 0.74 | ACHE (0.51) | ACHEBCHEMAOBMAOA | |
| SCHEMBL9260006 | 0.73 | CNR1 (0.53) | ACHEBCHEALDH1A1KDM4EHPGD | |
| SCHEMBL9251106 | 0.71 | KDM4E (0.51) | ACHEALDH1A1KDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |