Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMM2 | O15305 | 1/20 | 0.45 |
| ▸ | IDE | P14735 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 5/20 | 0.42 |
| ▸ | RXRB | P28702 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9262493 | 0.94 | MAPT (0.46) | PMM2IDEMPIPHOSPHO1APOBEC3G | |
| SCHEMBL28550660 | 0.83 | KAT2B (0.46) | PMM2MPIPHOSPHO1APOBEC3GKDM4E | |
| SCHEMBL21887490 | 0.73 | KAT2B (0.56) | RXRARXRBCA12CA1CA2 | |
| SCHEMBL9265797 | 0.73 | MYC (0.45) | KDM4EALDH1A1KMT2AMAPTTDP1 | |
| SCHEMBL28551232 | 0.70 | KAT2B (0.46) | PMM2MPIPHOSPHO1APOBEC3GKDM4E | |
| SCHEMBL27816597 | 0.68 | RAB9A (0.63) | EGFRKMT2AMEN1POLB | |
| SCHEMBL2346605 | 0.67 | KMO (0.76) | RXRARXRBEGFRRXRGBCL2 | |
| SCHEMBL29906143 | 0.67 | KMO (0.76) | RXRARXRBEGFRRXRGBCL2 | |
| Ethane SCHEMBL27330257 | 0.66 | MAPT (0.67) | RXRARXRBEGFRRXRGBCL2 | |
| SCHEMBL7155730 | 0.66 | EGFR (0.72) | EGFRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5411977-A | Substituted 2,5-diaryl-4-isothiazolin-3-ones as antiinflammatory and antithrombotic agents | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-05-02 | — | — | US | disclosed |