Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | UBE2M | P61081 | 8/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255999 | 0.86 | HDAC3 (0.50) | THRBLMNAUBE2MDCUN1D1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9260586 | 0.85 | THRB (0.46) | THRBLMNAUBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL9262760 | 0.85 | LMNA (0.59) | THRBSMN1; SMN2LMNANPSR1UBE2M | |
| Hydrochloric Acid SCHEMBL9259182 | 0.85 | HDAC3 (0.49) | THRBLMNAUBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL9256017 | 0.83 | ALDH1A1 (0.66) | SMN1; SMN2LMNAUBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL10888264 | 0.82 | UBE2M (0.57) | UBE2MDCUN1D1ABCC1 | |
| SCHEMBL9257297 | 0.82 | DCUN1D1 (0.56) | SMN1; SMN2UBE2MDCUN1D1ALDH1A1TP53 | |
| SCHEMBL9257490 | 0.82 | UBE2M (0.54) | THRBNPSR1UBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL13911220 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1ALDH1A1ABCC1 | |
| SCHEMBL9059369 | 0.81 | GAA (0.49) | THRBNPSR1UBE2MDCUN1D1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |