Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27340085 | 1.00 | IDH1 (0.48) | IDH1CYP2D6KMT2ACYP3A4CYP3A5 | |
| SCHEMBL9255788 | 0.87 | ACHE (0.52) | IDH1CYP2D6KMT2ACYP3A4ATM | |
| SCHEMBL27342830 | 0.87 | ACHE (0.52) | IDH1CYP2D6KMT2ACYP3A4ATM | |
| SCHEMBL27363283 | 0.87 | OPRD1 (0.54) | IDH1KMT2AOPRD1OPRM1OPRK1 | |
| SCHEMBL9217851 | 0.87 | OPRD1 (0.54) | IDH1KMT2AOPRD1OPRM1OPRK1 | |
| SCHEMBL9254262 | 0.83 | DRD2 (0.51) | IDH1CYP2D6KMT2ACYP3A4CYP3A5 | |
| SCHEMBL9253495 | 0.80 | OPRD1 (0.49) | IDH1CYP2D6KMT2ACYP3A4CYP3A5 | |
| SCHEMBL9255737 | 0.80 | IDH1 (0.54) | IDH1CYP2D6KMT2AOPRD1DRD2 | |
| SCHEMBL7952124 | 0.74 | OPRD1 (0.54) | IDH1KMT2AOPRD1OPRM1OPRK1 | |
| SCHEMBL3323053 | 0.74 | ALDH1A1 (0.45) | IDH1CYP2D6ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470851-A | Antihistamine, anticoagulants | SANKYO COMPANY, LIMITED (JP) | 1995-11-28 | — | — | US | disclosed |
| CN-1058780-A | Has the active thiazolidine carboxylic acid amides derivative of anti-allergy, their preparation and application | SANKYO CO (JP) | 1992-02-19 | — | — | CN | disclosed |
| EP-0463873-A1 | Thiazolidinecarboxylic acid amide derivatives having anti-allergic activity, their preparation and their use | Sankyo Company Limited (JP) | 1992-01-02 | — | — | EP | disclosed |