Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8595377 | 0.92 | SMN1; SMN2 (0.39) | POLBSMN1; SMN2AOC3NPC1RAB9A | |
| SCHEMBL9131392 | 0.89 | POLB (0.38) | POLBSMN1; SMN2AOC3NPC1RAB9A | |
| SCHEMBL4888374 | 0.85 | POLB (0.39) | POLBSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL2564080 | 0.84 | SMN1; SMN2 (0.37) | POLBSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL29954781 | 0.84 | SMN1; SMN2 (0.37) | POLBSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL27357705 | 0.78 | POLB (0.38) | POLBSMN1; SMN2AOC3NPC1RAB9A | |
| SCHEMBL8596999 | 0.78 | POLB (0.38) | POLBSMN1; SMN2AOC3NPC1RAB9A | |
| SCHEMBL6188044 | 0.77 | GRM5 (0.39) | POLBSMN1; SMN2AOC3NPC1RAB9A | |
| SCHEMBL4990435 | 0.76 | SMN1; SMN2 (0.36) | POLBSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL8788397 | 0.75 | NPSR1 (0.55) | SMN1; SMN2NPC1RAB9AL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430149-A | 5-[(4-bromophenyl)methyl]4-pyrimidinones | SYNTHELABO (FR) | 1995-07-04 | — | — | US | disclosed |
| US-5312920-A | Process for preparing 4-pyrimidinones | SYNTHELABO (FR) | 1994-05-17 | — | — | US | disclosed |