Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253016 | 0.93 | MRGPRX1 (0.40) | — | |
| SCHEMBL9256103 | 0.80 | CHRNA7 (0.34) | CHRM1CHRM2 | |
| SCHEMBL9253640 | 0.80 | SLC6A4 (0.40) | SLC6A3CHRM1SLC6A2SLC6A4TSHR | |
| SCHEMBL4674804 | 0.79 | IDO1 (0.39) | IDO1 | |
| SCHEMBL7319671 | 0.76 | SLC6A2 (0.45) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL9257882 | 0.76 | ALDH1A1 (0.41) | SLC6A3CHRM1SLC6A2SLC6A4TSHR | |
| Hydrochloric Acid SCHEMBL9768345 | 0.74 | SLC6A2 (0.46) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL7433281 | 0.74 | CYP19A1 (0.47) | — | |
| SCHEMBL9668878 | 0.74 | OPRD1 (0.40) | — | |
| SCHEMBL9253506 | 0.74 | IDO1 (0.41) | SLC6A3CHRM1SLC6A2SLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470851-A | Antihistamine, anticoagulants | SANKYO COMPANY, LIMITED (JP) | 1995-11-28 | — | — | US | claimed |
| EP-0463873-A1 | Thiazolidinecarboxylic acid amide derivatives having anti-allergic activity, their preparation and their use | Sankyo Company Limited (JP) | 1992-01-02 | — | — | EP | claimed |
| EP-0299663-A2 | Antihistaminic aromatic tetrahydroazepinones (and thiones) | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1989-01-18 | — | — | EP | claimed |
| US-4783535-A | Chemical intermediates in the preparation of aromatic-1,4-oxazepinones and thiones | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-11-08 | — | — | US | claimed |
| US-4746657-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-05-24 | — | — | US | claimed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | claimed |
| US-4610819-A | Process for the preparation of aromatic-1,4-oxazepinones and thiones | A. H. ROBINS COMPANY, INC. (US) | 1986-09-09 | — | — | US | claimed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | claimed |
| EP-0175570-A2 | Process for the preparation of aromatic-1,4-oxazepinones and thiones | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1986-03-26 | — | — | EP | claimed |
| US-5470851-A | Antihistamine, anticoagulants | SANKYO COMPANY, LIMITED (JP) | 1995-11-28 | — | — | US | disclosed |
| EP-0463873-A1 | Thiazolidinecarboxylic acid amide derivatives having anti-allergic activity, their preparation and their use | Sankyo Company Limited (JP) | 1992-01-02 | — | — | EP | disclosed |
| US-4812565-A | ANTIHISTAMINE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-14 | — | — | US | disclosed |
| US-4810795-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0299663-A2 | Antihistaminic aromatic tetrahydroazepinones (and thiones) | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1989-01-18 | — | — | EP | disclosed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4642343-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4610819-A | Process for the preparation of aromatic-1,4-oxazepinones and thiones | A. H. ROBINS COMPANY, INC. (US) | 1986-09-09 | — | — | US | disclosed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | disclosed |
| US-4592866-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0175570-A2 | Process for the preparation of aromatic-1,4-oxazepinones and thiones | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1986-03-26 | — | — | EP | disclosed |