Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 8/20 | 0.36 |
| ▸ | FNTB | P49356 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259169 | 0.87 | MAPT (0.44) | MAPTGABBR2GABBR1MEN1LMNA | |
| SCHEMBL9263580 | 0.87 | MAPT (0.40) | MAPTMEN1LMNAKMT2AALDH1A1 | |
| Methyl Alcohol SCHEMBL9254484 | 0.84 | MAPT (0.45) | MAPTGABBR2GABBR1MEN1KMT2A | |
| SCHEMBL9263736 | 0.83 | MAPK1 (0.46) | MAPTGABBR2GABBR1LMNAKMT2A | |
| SCHEMBL9257787 | 0.77 | CYP1A2 (0.43) | MAPTALDH1A1POLBCYP1A2 | |
| SCHEMBL7655013 | 0.77 | MAPT (0.55) | MAPTGABBR2GABBR1MEN1LMNA | |
| SCHEMBL9263236 | 0.76 | CYP3A4 (0.42) | MEN1KMT2AALDH1A1ATM | |
| SCHEMBL9261597 | 0.72 | GABBR2 (0.51) | MAPTGABBR2GABBR1MEN1LMNA | |
| Methyl Alcohol SCHEMBL9267439 | 0.72 | ALDH1A1 (0.45) | LMNAALDH1A1L3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL9264723 | 0.71 | TDP1 (0.46) | MAPTLMNAKMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |