Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265963 | 0.96 | TSPO (0.46) | TSPOGABRA2GABRB2SLC2A1MAT2A | |
| SCHEMBL9261406 | 0.89 | KDM4E (0.43) | GABRA2GABRB2HPGDKDM4EADORA2B | |
| SCHEMBL9264676 | 0.88 | GABRA1 (0.46) | GABRA2GABRB2NR4A2HPGDKDM4E | |
| SCHEMBL9264404 | 0.87 | KDM4E (0.41) | GABRA2GABRB2SLC2A1KDM4EADORA2B | |
| SCHEMBL9261917 | 0.87 | GABRA1 (0.47) | TSPOGABRA2GABRB2HPGDKDM4E | |
| SCHEMBL9258447 | 0.86 | NR4A2 (0.43) | GABRA2GABRB2NR4A2HPGDKDM4E | |
| SCHEMBL9264565 | 0.85 | ADORA2B (0.42) | MAT2AKDM4EADORA2B | |
| SCHEMBL9262280 | 0.85 | KDM4E (0.46) | GABRA2GABRB2HPGDKDM4EADORA2B | |
| SCHEMBL9261380 | 0.81 | MAPT (0.41) | MAT2AKDM4EADORA2B | |
| SCHEMBL9263087 | 0.81 | GABRA1 (0.54) | TSPOGABRA2GABRB2NR4A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466706-A | Compounds for hypnotics, anxiety or anticonvulsants | SYNTHELABO (FR) | 1995-11-14 | — | — | US | disclosed |
| EP-0607076-A1 | 9H-Imidazo 1,2-a benzimidazole derivatives with GABA activity | SYNTHELABO (FR) | 1994-07-20 | — | — | EP | disclosed |