Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | FGB | P02675 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 2/20 | 0.37 |
| ▸ | CDC25B | P30305 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200679 | 0.75 | PKM (0.46) | APEX1ALDH1A1POLBHSD17B10TSHR | |
| SCHEMBL9072653 | 0.72 | APEX1 (0.47) | APEX1ALDH1A1POLBHSD17B10TSHR | |
| SCHEMBL5717731 | 0.69 | HPGD (0.47) | APEX1ALDH1A1POLBHSD17B10TSHR | |
| SCHEMBL2330404 | 0.68 | RPS6KB2 (0.49) | ALDH1A1POLBHSD17B10TSHRHPGD | |
| SCHEMBL6405494 | 0.68 | ALDH1A1 (0.53) | APEX1ALDH1A1POLBTSHRHPGD | |
| SCHEMBL9701297 | 0.67 | MEN1 (0.54) | ALDH1A1POLBHSD17B10TSHRHPGD | |
| SCHEMBL1930794 | 0.65 | ALDH1A1 (0.77) | ALDH1A1TSHRHPGDMAPK1SMN1; SMN2 | |
| E388 SCHEMBL11805388 | 0.65 | HSD17B10 (0.64) | ALDH1A1HSD17B10TSHRHPGDMAPK1 | |
| SCHEMBL8534803 | 0.64 | KMT2A (0.44) | APEX1ALDH1A1POLBHSD17B10TSHR | |
| SCHEMBL969935 | 0.63 | APEX1 (0.44) | APEX1ALDH1A1POLBHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391564-A | E.g., rhizoxin-13-yl 3-methylthiopropionate; anticarcinogenic agents | SANKYO COMPANY, LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0350315-B1 | RHIZOXIN DERIVATES AND THEIR USE AS ANTI-TUMOR AGENTS | SANKYO COMPANY LIMITED (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0350315-A1 | Rhizoxin derivates and their use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |