Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9256039 | 1.00 | PTGES (0.53) | PTGESALDH1A1KDM4ETSHRUSP2 | |
| SCHEMBL11447172 | 0.82 | POLB (0.59) | ALDH1A1KDM4ETSHRUSP2NPSR1 | |
| SCHEMBL16118658 | 0.82 | DCUN1D1 (0.55) | PTGESALDH1A1KDM4ETSHRUSP2 | |
| SCHEMBL9256017 | 0.81 | ALDH1A1 (0.66) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9257531 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KDM4EUSP2NPSR1HPGD | |
| SCHEMBL23699970 | 0.80 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRUSP2NPSR1 | |
| SCHEMBL16118653 | 0.80 | DCUN1D1 (0.56) | PTGESALDH1A1KDM4ETSHRUSP2 | |
| SCHEMBL19570424 | 0.79 | EPHX2 (0.62) | ALDH1A1KDM4ETSHRUSP2EPHX2 | |
| SCHEMBL9260667 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNASMN1; SMN2POLB | |
| SCHEMBL9265694 | 0.78 | MEN1 (0.48) | ALDH1A1KDM4EAGER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |