Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | AGER | Q15109 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9256017 | 0.84 | ALDH1A1 (0.66) | ALDH1A1LMNASMN1; SMN2UBE2MDCUN1D1 | |
| SCHEMBL9258501 | 0.81 | PTGES (0.53) | ALDH1A1HPGDUSP2KDM4EHSD17B10 | |
| SCHEMBL9256039 | 0.81 | PTGES (0.53) | ALDH1A1HPGDUSP2KDM4EHSD17B10 | |
| SCHEMBL9265694 | 0.81 | MEN1 (0.48) | ALDH1A1KDM4EAGERL3MBTL1KMT2A | |
| SCHEMBL13900757 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HPGDUSP2KDM4EHSD17B10 | |
| SCHEMBL16118655 | 0.80 | HTR2A (0.59) | ALDH1A1HPGDUSP2KDM4EHSD17B10 | |
| SCHEMBL9255999 | 0.78 | HDAC3 (0.50) | ALDH1A1LMNAAGERMTNR1AUBE2M | |
| SCHEMBL9256274 | 0.78 | THRB (0.56) | ALDH1A1LMNAMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL9260667 | 0.77 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTSMN1; SMN2UBE2M | |
| SCHEMBL9264823 | 0.77 | LMNA (0.51) | ALDH1A1KDM4ELMNAMAPTAGER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |