Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28640674 | 0.73 | SLC6A2 (0.44) | SLC6A3SLC6A2SLC6A4NFE2L2SMN1; SMN2 | |
| SCHEMBL4130950 | 0.71 | SRC (0.41) | LMNAALDH1A1 | |
| SCHEMBL15652756 | 0.69 | ALDH1A1 (0.36) | NFE2L2LMNASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL14029083 | 0.69 | HTR6 (0.70) | LMNASMN1; SMN2ALDH1A1TDP1NOTUM | |
| SCHEMBL438263 | 0.69 | SRC (0.40) | LMNAALDH1A1 | |
| SCHEMBL5555043 | 0.67 | SRC (0.39) | LMNAALDH1A1 | |
| SCHEMBL669211 | 0.67 | SRC (0.54) | LMNASMN1; SMN2ALDH1A1TDP1KDM4E | |
| SCHEMBL3633092 | 0.67 | ALDH1A1 (0.42) | LMNAALDH1A1TDP1HSD17B10 | |
| SCHEMBL9006009 | 0.67 | CA1 (0.42) | ALDH1A1 | |
| SCHEMBL5555050 | 0.67 | SRC (0.39) | SLC6A2LMNAALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995009158-A1 | TRICYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1995-04-06 | — | — | WO | disclosed |
| WO-1994007869-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1994-04-14 | — | — | WO | disclosed |