SCHEMBL9259301

SCHEMBL9259301

NNc1nc(CCl)nc2ccc(Cl)cc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
GAA P10253 2/20 0.44
MAPT P10636 2/20 0.44
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
HTT P42858 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
LMNA P02545 1/20 0.40
ALOX12 P18054 1/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PIK3CD O00329 2/20 0.39
PIK3R1 P27986 2/20 0.39
HRH4 Q9H3N8 2/20 0.37
HTR3A P46098 2/20 0.37
ACHE P22303 4/20 0.37
BCHE P06276 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9269176 0.83 MAPT (0.39) ALDH1A1GAAMAPTHTTKDM4E
SCHEMBL9265990 0.83 LMNA (0.41) ALDH1A1MAPTHTTKDM4ENPC1
SCHEMBL404108 0.80 ALDH1A1 (0.53) ALDH1A1GAAMAPTCYP1A2CYP2D6
SCHEMBL9260020 0.79 MAPT (0.53) ALDH1A1GAAMAPTHTTMEN1
SCHEMBL9266044 0.78 KDM4E (0.44) ALDH1A1MAPTHTTKDM4ENPC1
SCHEMBL31663132 0.76 MPO (0.51) ALDH1A1MAPTKDM4EMEN1NPC1
SCHEMBL11807689 0.72 KDM4E (0.59) ALDH1A1GAAMAPTKDM4EMEN1
SCHEMBL11685844 0.70 CYP1A2 (0.65) ALDH1A1MAPTCYP1A2CYP2D6HTT
SCHEMBL9258621 0.69 GRIN1 (0.36) ALDH1A1GAAMAPTMEN1LMNA
SCHEMBL11634646 0.69 HSP90AB1 (0.48) ALDH1A1GAAMAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5387585-A Treating epilepsy, anxiety, sleep disorders, schizophrnia, senile dementia HOFFMANN-LA ROCHE INC. (US) 1995-02-07 US disclosed
EP-0519307-A2 Tetracyclic Imidazodiazepines F. HOFFMANN-LA ROCHE AG (CH) 1992-12-23 EP disclosed