Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.46 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.46 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259446 | 0.83 | DRD1 (0.64) | DRD1DRD2DRD4GRIN2DGRIN3B | |
| SCHEMBL21346108 | 0.79 | DRD2 (0.65) | DRD1DRD2DRD4KCNH2LMNA | |
| SCHEMBL21346707 | 0.79 | DRD2 (0.65) | DRD1DRD2DRD4KCNH2LMNA | |
| SCHEMBL20170794 | 0.78 | DRD2 (0.67) | DRD1DRD2DRD4KCNH2LMNA | |
| SCHEMBL5108458 | 0.77 | KDM4E (0.72) | DRD1DRD2DRD4KCNH2LMNA | |
| SCHEMBL19629885 | 0.77 | OPRM1 (0.60) | DRD1DRD2SLC6A4MAPK1CYP2D6 | |
| SCHEMBL8024197 | 0.77 | MAOA (0.60) | DRD1DRD2DRD4DRD5DRD3 | |
| SCHEMBL9263978 | 0.76 | MTNR1B (0.56) | DRD1DRD2DRD4GRIN2DGRIN3B | |
| SCHEMBL5514232 | 0.74 | DRD1 (0.53) | DRD1DRD2DRD4GRIN2DGRIN3B | |
| SCHEMBL10222659 | 0.73 | DRD2 (0.78) | DRD1DRD2KCNH2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995007260-A1 | TETRAHYDROISOQUINOLINES AS ALPHA-2 ANTAGONISTS AND BIOGENIC AMINE UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1995-03-16 | — | — | WO | disclosed |
| US-5389638-A | Nervous system disorders | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |