Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976764 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL3068412 | 0.82 | MAPT (0.53) | SMN1; SMN2MAPTLIN28ATDP1HRH1 | |
| SCHEMBL21994253 | 0.81 | MAPT (0.52) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL7660360 | 0.80 | MEN1 (0.49) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL825216 | 0.78 | TDP1 (0.45) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL427048 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL6204342 | 0.77 | KDM4E (0.52) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL427047 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL7976763 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTLIN28ATDP1KMT2A | |
| SCHEMBL27322956 | 0.76 | BAZ2B (0.43) | MAPTTDP1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378706-A | Memory disorders, senile dememtia | SANOFI (FR) | 1995-01-03 | — | — | US | disclosed |
| US-5232921-A | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions | SANOFI (FR) | 1993-08-03 | — | — | US | disclosed |