Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259854 | 1.00 | MTNR1A (0.45) | MTNR1AMTNR1BCTSKCYP1A2CYP3A4 | |
| SCHEMBL9264273 | 0.89 | CYP1A2 (0.46) | MTNR1AMTNR1BCTSKCYP1A2CYP3A4 | |
| SCHEMBL9264279 | 0.89 | CYP1A2 (0.46) | MTNR1AMTNR1BCTSKCYP1A2CYP3A4 | |
| SCHEMBL9259467 | 0.86 | CTSK (0.41) | CTSKDDB1CRBNNPC1RAB9A | |
| SCHEMBL9263608 | 0.86 | CTSK (0.41) | CTSKCYP3A4CYP2C19DDB1CRBN | |
| SCHEMBL9263612 | 0.86 | CTSK (0.41) | CTSKCYP3A4CYP2C19DDB1CRBN | |
| SCHEMBL9259463 | 0.86 | CTSK (0.41) | CTSKDDB1CRBNNPC1RAB9A | |
| SCHEMBL9261965 | 0.85 | NPC1 (0.47) | CTSKCYP1A2CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL9261958 | 0.85 | NPC1 (0.47) | CTSKCYP1A2CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL9259375 | 0.84 | MAPT (0.46) | MTNR1AMTNR1BCTSKCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476944-A | Inhibitors or stimulators of superoxide generation; may also inhibit cyclooxygenase and/or 5-lipoxygenase; useful in therapeutic or prophylactic treatment of disease conditions | G. D. SEARLE & CO. (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0613463-A1 | DERIVATIVES OF CYCLIC PHENOLIC THIOETHERS AS INHIBITORS OR STIMULATORS OF SUPEROXIDE GENERATION | G.D. SEARLE & CO. (US) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010087-A1 | DERIVATIVES OF CYCLIC PHENOLIC THIOETHERS AS INHIBITORS OR STIMULATORS OF SUPEROXIDE GENERATION | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |