Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | GAA | P10253 | 2/20 | 0.79 |
| ▸ | HPGD | P15428 | 2/20 | 0.79 |
| ▸ | CASP1 | P29466 | 2/20 | 0.79 |
| ▸ | CASP7 | P55210 | 2/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | SRC | P12931 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | ATM | Q13315 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.79 |
| ▸ | AGER | Q15109 | 2/20 | 0.60 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 8/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29356441 | 0.89 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL144309 | 0.89 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDCASP1 | |
| Dl-Phenylalanine SCHEMBL28868219 | 0.86 | KDM4E (0.59) | KDM4EALDH1A1GAAHPGDCASP1 | |
| Proline SCHEMBL28395374 | 0.85 | TLR9 (0.57) | KDM4EALDH1A1GAAHPGDCASP1 | |
| Alanine SCHEMBL15556780 | 0.85 | KDM4E (0.75) | KDM4EALDH1A1GAAHPGDCASP1 | |
| Glycine SCHEMBL335759 | 0.80 | ALDH1A1 (0.77) | KDM4EALDH1A1GAAHPGDCASP1 | |
| Glycine SCHEMBL4176892 | 0.78 | ALDH1A1 (0.75) | KDM4EALDH1A1GAAHPGDCASP1 | |
| Glycine SCHEMBL4627607 | 0.78 | ALDH1A1 (0.75) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL7120858 | 0.78 | KDM4E (0.64) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL1771156 | 0.77 | KDM4E (0.77) | KDM4EALDH1A1GAAHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496680-B1 | Procedure and medium to identify bacteria of the genus Listeria | BIO MERIEUX (FR) | 1995-09-06 | — | — | EP | claimed |
| US-5330889-A | Colorimetric, fluorescence, enzymatic hydrolysis of substrate | BIO MERIEUX (FR) | 1994-07-19 | — | — | US | claimed |
| EP-0496680-A1 | Procedure and medium to identify bacteria of the genus Listeria | BIO MERIEUX, Société anonyme (FR) | 1992-07-29 | — | — | EP | claimed |
| EP-0496680-B1 | Procedure and medium to identify bacteria of the genus Listeria | BIO MERIEUX (FR) | 1995-09-06 | — | — | EP | disclosed |
| US-5330889-A | Colorimetric, fluorescence, enzymatic hydrolysis of substrate | BIO MERIEUX (FR) | 1994-07-19 | — | — | US | disclosed |
| EP-0496680-A1 | Procedure and medium to identify bacteria of the genus Listeria | BIO MERIEUX, Société anonyme (FR) | 1992-07-29 | — | — | EP | disclosed |