Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 3/20 | 0.60 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22722201 | 0.81 | HDAC8 (0.59) | MMP3HDAC8PLK1MEN1KMT2A | |
| SCHEMBL9830733 | 0.81 | MMP3 (0.54) | MMP3HDAC8PLK1MEN1KMT2A | |
| SCHEMBL9830741 | 0.81 | MMP3 (0.54) | MMP3HDAC8PLK1MEN1KMT2A | |
| SCHEMBL22648637 | 0.80 | TACR3 (0.57) | TACR3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL12218397 | 0.79 | ALDH1A1 (0.65) | TACR3MMP3HDAC8PLK1ALDH1A1 | |
| SCHEMBL19813081 | 0.79 | HPGD (0.56) | TACR3KCNA5ALDH1A1HPGDLMNA | |
| SCHEMBL5643849 | 0.79 | NPC1 (0.55) | TACR3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL28015856 | 0.79 | ALDH1A1 (0.60) | TACR3KCNA5MEN1KMT2AALDH1A1 | |
| SCHEMBL12260876 | 0.78 | KDM4E (0.56) | TACR3KCNA5ALDH1A1HPGDLMNA | |
| SCHEMBL8855769 | 0.78 | KDM4E (0.51) | TACR3KCNA5ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995007260-A1 | TETRAHYDROISOQUINOLINES AS ALPHA-2 ANTAGONISTS AND BIOGENIC AMINE UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1995-03-16 | — | — | WO | disclosed |
| US-5389638-A | Nervous system disorders | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |