Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9267937 | 0.91 | MAOA (0.40) | SMN1; SMN2HTTHSD17B10L3MBTL1HPGD | |
| SCHEMBL9266335 | 0.83 | PDE2A (0.36) | HSD17B10L3MBTL1HPGDMAPTMAPK1 | |
| SCHEMBL9261097 | 0.81 | MAOA (0.40) | SMN1; SMN2HSD17B10L3MBTL1HPGDKDM4E | |
| SCHEMBL4573388 | 0.78 | ALDH1A1 (0.40) | SMN1; SMN2HTTHSD17B10L3MBTL1HPGD | |
| SCHEMBL30230932 | 0.77 | MAOA (0.48) | SMN1; SMN2HSD17B10L3MBTL1HPGDKDM4E | |
| SCHEMBL900450 | 0.77 | MAOA (0.48) | SMN1; SMN2HSD17B10L3MBTL1HPGDKDM4E | |
| SCHEMBL28136881 | 0.72 | MAOA (0.42) | SMN1; SMN2HTTHSD17B10L3MBTL1HPGD | |
| SCHEMBL29462008 | 0.71 | KMT2A (0.43) | SMN1; SMN2HTTHSD17B10L3MBTL1HPGD | |
| SCHEMBL3040297 | 0.71 | KMT2A (0.43) | SMN1; SMN2HTTHSD17B10L3MBTL1HPGD | |
| SCHEMBL9682836 | 0.71 | LMNA (0.45) | SMN1; SMN2HTTL3MBTL1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430042-A | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use | AKTIEBOLAGET ASTRA (SE) | 1995-07-04 | — | — | US | disclosed |
| EP-0593463-A1 | DIALKOXY-PYRIDINYL-BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019712-A1 | DIALKOXY-PYRIDINYL-BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1991-12-26 | — | — | WO | disclosed |