SCHEMBL926068

SCHEMBL926068

C[Si](C)(C)CNC(=O)c1ccc(F)c(Br)c1

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.47
ALDH1A1 P00352 3/20 0.46
HDAC1 Q13547 4/20 0.44
HDAC6 Q9UBN7 4/20 0.44
RAB9A P51151 3/20 0.40
NPC1 O15118 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
MAOB P27338 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
LMNA P02545 1/20 0.39
DDR1 Q08345 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16224267 0.94 ALDH1A1 (0.45) HPGDALDH1A1HDAC1HDAC6RAB9A
SCHEMBL13702278 0.83 HPGD (0.47) HPGDALDH1A1HDAC1HDAC6RAB9A
SCHEMBL13859182 0.82 SMN1; SMN2 (0.53) HPGDRAB9ANPC1SMN1; SMN2MAOB
SCHEMBL901725 0.81 HPGD (0.52) HPGDALDH1A1HDAC1HDAC6RAB9A
SCHEMBL15492007 0.81 ALDH1A1 (0.48) HPGDALDH1A1HDAC6RAB9ANPC1
SCHEMBL938064 0.81 HPGD (0.46) HPGDALDH1A1HDAC6RAB9ANPC1
SCHEMBL15492067 0.81 HPGD (0.49) HPGDALDH1A1RAB9ANPC1L3MBTL1
SCHEMBL902163 0.80 MAPT (0.50) HPGDALDH1A1HDAC1HDAC6NPSR1
SCHEMBL15492049 0.79 HPGD (0.45) HPGDALDH1A1RAB9ANPC1L3MBTL1
SCHEMBL19771763 0.79 HPGD (0.43) HPGDALDH1A1HDAC1HDAC6RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180098542-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2018-04-12 US disclosed
US-20180098542-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2018-04-12 US disclosed
US-9867375-B2 Methods of pest control in soybean SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 US disclosed
US-9867375-B2 Methods of pest control in soybean SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 US disclosed
US-20150237862-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2015-08-27 US disclosed
US-20150237862-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2015-08-27 US disclosed
US-20150237862-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2015-08-27 US disclosed
US-20150208658-A1 METHODS OF SOIL PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2015-07-30 US disclosed
US-20150208658-A1 METHODS OF SOIL PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2015-07-30 US disclosed
US-20150208658-A1 METHODS OF SOIL PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2015-07-30 US disclosed
WO-2014029707-A1 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014019609-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2014-02-06 WO disclosed
CN-101939295-B Insecticidal arylpyrrolines BAYER CROPSCIENCE AG 2013-04-24 CN disclosed
US-8304371-B2 Insecticidal arylpyrrolines BAYER CROPSCIENCE AG (DE) 2012-11-06 US disclosed
US-8304371-B2 Insecticidal arylpyrrolines BAYER CROPSCIENCE AG (DE) 2012-11-06 US disclosed
US-20110003690-A1 INSECTICIDAL ARYLPYRROLINES BAY CROPSCIENCE AG (DE) 2011-01-06 US disclosed
US-20110003690-A1 INSECTICIDAL ARYLPYRROLINES BAY CROPSCIENCE AG (DE) 2011-01-06 US disclosed
CN-101939295-A Insecticidal arylpyrrolines BAYER CROPSCIENCE AG 2011-01-05 CN disclosed
EP-2242739-A1 INSECTICIDAL ARYLPYRROLINES Bayer CropScience AG (DE) 2010-10-27 EP disclosed
WO-2009097992-A1 INSECTICIDAL ARYLPYRROLINES BAYER CROPSCIENCE AG (DE) 2009-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180098542-A1 METHODS OF PEST CONTROL IN SOYBEAN BTF3, BRS3, CCNB3 HPGD 4055/4885ALDH1A1 4511/4885HDAC1 3466/4885
US-20150208658-A1 METHODS OF SOIL PEST CONTROL C1S, CBR3, CNPY3 HPGD 4142/4885ALDH1A1 3946/4885HDAC1 3224/4885
US-20110003690-A1 INSECTICIDAL ARYLPYRROLINES DDT, ACHE, CYP1A2 HPGD 1549/4885ALDH1A1 127/4885HDAC1 189/4885
US-20150237862-A1 METHODS OF PEST CONTROL IN SOYBEAN HRH4, HRH3, H1-3 HPGD 3899/4885ALDH1A1 4444/4885HDAC1 3614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.