SCHEMBL938064

SCHEMBL938064

C[Si](C)(C)CNC(=O)c1ccc(CBr)c(Br)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.46
ALDH1A1 P00352 3/20 0.45
L3MBTL1 Q9Y468 2/20 0.39
LMNA P02545 2/20 0.39
KDM4E B2RXH2 2/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
NPSR1 Q6W5P4 1/20 0.38
NPC1 O15118 2/20 0.38
CNR2 P34972 2/20 0.37
HDAC6 Q9UBN7 1/20 0.36
MAPT P10636 1/20 0.36
GAA P10253 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CNR1 P21554 1/20 0.36
MTOR P42345 1/20 0.36
PPARG P37231 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27825734 0.89 HPGD (0.44) HPGDALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL15492007 0.88 ALDH1A1 (0.48) HPGDALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL936308 0.82 HPGD (0.41) HPGDALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL926068 0.81 HPGD (0.47) HPGDALDH1A1L3MBTL1LMNARAB9A
SCHEMBL901725 0.80 HPGD (0.52) HPGDALDH1A1RAB9ASMN1; SMN2NPSR1
SCHEMBL27825735 0.80 HPGD (0.44) HPGDALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL15492067 0.79 HPGD (0.49) HPGDALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL902163 0.79 MAPT (0.50) HPGDALDH1A1LMNAKDM4EHTT
SCHEMBL15492049 0.78 HPGD (0.45) HPGDALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL28003687 0.76 CES2 (0.44) RAB9ASMN1; SMN2NPC1HDAC6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180098542-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2018-04-12 US disclosed
US-9867375-B2 Methods of pest control in soybean SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 US disclosed
US-20150237862-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2015-08-27 US disclosed
US-20150208658-A1 METHODS OF SOIL PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2015-07-30 US disclosed
US-20150189884-A1 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2015-07-09 US disclosed
EP-2887802-A2 METHODS OF SOIL PEST CONTROL Syngenta Participations AG (CH) 2015-07-01 EP disclosed
EP-2242739-B1 INSECTICIDAL ARYLPYRROLINES BAYER CROPSCIENCE AG (DE) 2014-11-12 EP disclosed
EP-2242739-B1 INSECTICIDAL ARYLPYRROLINES BAYER CROPSCIENCE AG (DE) 2014-11-12 EP disclosed
WO-2014029707-A1 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014029706-A2 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014029710-A2 METHODS OF SOIL PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014029708-A1 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014019609-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2014-02-06 WO disclosed
US-8304371-B2 Insecticidal arylpyrrolines BAYER CROPSCIENCE AG (DE) 2012-11-06 US disclosed
US-8304371-B2 Insecticidal arylpyrrolines BAYER CROPSCIENCE AG (DE) 2012-11-06 US disclosed
US-20110003690-A1 INSECTICIDAL ARYLPYRROLINES BAY CROPSCIENCE AG (DE) 2011-01-06 US disclosed
US-20110003690-A1 INSECTICIDAL ARYLPYRROLINES BAY CROPSCIENCE AG (DE) 2011-01-06 US disclosed
EP-2242739-A1 INSECTICIDAL ARYLPYRROLINES Bayer CropScience AG (DE) 2010-10-27 EP disclosed
WO-2009097992-A1 INSECTICIDAL ARYLPYRROLINES BAYER CROPSCIENCE AG (DE) 2009-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180098542-A1 METHODS OF PEST CONTROL IN SOYBEAN BTF3, BRS3, CCNB3 HPGD 4055/4885ALDH1A1 4511/4885L3MBTL1 66/4885
US-20150189884-A1 METHODS OF CONTROLLING INSECTS CBR3, C5, CNPY3 HPGD 4158/4885ALDH1A1 4341/4885L3MBTL1 15/4885
US-20150208658-A1 METHODS OF SOIL PEST CONTROL C1S, CBR3, CNPY3 HPGD 4142/4885ALDH1A1 3946/4885L3MBTL1 20/4885
US-20110003690-A1 INSECTICIDAL ARYLPYRROLINES DDT, ACHE, CYP1A2 HPGD 1549/4885ALDH1A1 127/4885L3MBTL1 1028/4885
US-20150237862-A1 METHODS OF PEST CONTROL IN SOYBEAN HRH4, HRH3, H1-3 HPGD 3899/4885ALDH1A1 4444/4885L3MBTL1 68/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.