⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14459543 | 1.00 | — | — | |
| SCHEMBL196133 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL4591643 | 0.89 | TDP1 (0.40) | — | |
| SCHEMBL21777039 | 0.83 | MGAM (0.37) | — | |
| SCHEMBL31210051 | 0.83 | CA1 (0.33) | — | |
| SCHEMBL12234493 | 0.82 | TSHR (0.40) | — | |
| SCHEMBL27494399 | 0.82 | LMNA (0.44) | — | |
| SCHEMBL27494398 | 0.82 | LMNA (0.44) | — | |
| SCHEMBL13898920 | 0.82 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL37035 | 0.82 | ALDH1A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250145629-A1 | ION CHANNEL MODULATORS | PRAXIS PRECISION MEDICINES, INC. | 2025-05-08 | — | — | US | disclosed |
| CN-113382767-B | Urea compounds having substituents | 第一三共株式会社 | 2024-12-24 | — | — | CN | disclosed |
| US-12145939-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators | PRAXIS PRECISION MEDICINES, INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-11981686-B2 | Urea compound having substituent | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2024-05-14 | — | — | US | disclosed |
| US-20240043433-A1 | ION CHANNEL MODULATORS | PRAXIS PRECISION MEDICINES, INC. | 2024-02-08 | — | — | US | disclosed |
| US-11767325-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-11767325-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-20230058950-A1 | UREA COMPOUND HAVING SUBSTITUENT | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2023-02-23 | — | — | US | disclosed |
| CN-113382767-A | Substituted urea compounds | 第一三共株式会社 | 2021-09-10 | — | — | CN | disclosed |
| US-8022069-B2 | Substituted piperidines as renin inhibitors | NOVARTIS AG (CH) | 2011-09-20 | — | — | US | disclosed |
| EP-2229384-A1 | ORGANIC COMPOUNDS | Speedel Experimenta AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| EP-2215088-A2 | 4,4-DISUBSTITUTED PIPERDINES AS RENIN INHIBITORS | Novartis AG (CH) | 2010-08-11 | — | — | EP | disclosed |
| EP-2212317-A1 | 4,4-DISUBSTITUTED PIPERIDINES | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009098276-A1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009074674-A2 | TRISUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-06-18 | — | — | WO | disclosed |
| WO-2009071606-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009056617-A2 | 4,4-DISUBSTITUTED PIPERDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009053452-A1 | 4,4-DISUBSTITUTED PIPERIDINES | NOVARTIS AG (CH) | 2009-04-30 | — | — | WO | disclosed |
| EP-1901724-A1 | PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING EPINASTINE | Senju Pharmaceutical Co., Ltd. (JP) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007007851-A1 | PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING EPINASTINE | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2007-01-18 | — | — | WO | disclosed |