SCHEMBL9264469

SCHEMBL9264469

CSc1ccc(Oc2ccc(C=O)cc2)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.76
CYP1A1 P04798 6/20 0.53
CYP1A2 P05177 6/20 0.53
CYP1B1 Q16678 6/20 0.53
CYP2A6 P11509 2/20 0.52
PARP10 Q53GL7 1/20 0.50
PARP3 Q9Y6F1 1/20 0.50
KDM4E B2RXH2 4/20 0.47
LMNA P02545 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
ALDH1A3 P47895 1/20 0.47
FBP1 P09467 1/20 0.42
STS P08842 1/20 0.41
MAPT P10636 3/20 0.41
POLB P06746 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HPGD P15428 1/20 0.40
HTR2A P28223 1/20 0.39
SLC6A4 P31645 1/20 0.39
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL195687 0.87 ALDH1A1 (1.00) ALDH1A1CYP1A1CYP1A2CYP1B1CYP2A6
SCHEMBL6855481 0.83 PARP10 (0.53) ALDH1A1CYP2A6PARP10PARP3KDM4E
SCHEMBL2774995 0.82 CYP1A1 (0.52) ALDH1A1CYP1A1CYP1A2CYP1B1HTR2A
SCHEMBL5050902 0.82 PARP10 (0.65) ALDH1A1CYP2A6PARP10PARP3KDM4E
SCHEMBL1663469 0.82 PARP10 (0.65) ALDH1A1CYP2A6PARP10PARP3KDM4E
SCHEMBL2149062 0.81 ALDH1A1 (0.86) ALDH1A1CYP1A1CYP1A2CYP1B1CYP2A6
SCHEMBL19914058 0.81 ALDH1A1 (0.86) ALDH1A1CYP1A1CYP1A2CYP1B1CYP2A6
Fluoromethane SCHEMBL28219755 0.81 ALDH1A1 (0.62) ALDH1A1CYP2A6PARP10PARP3KDM4E
SCHEMBL28066041 0.80 PARP10 (0.50) ALDH1A1CYP2A6PARP10PARP3KDM4E
SCHEMBL6142753 0.80 PARP10 (0.50) ALDH1A1CYP2A6PARP10PARP3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5403934-A Heterocyclic compounds BURROUGHS WELLCOME CO. (US) 1995-04-04 US disclosed
WO-1991013873-A1 HETEROCYCLIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1991-09-19 WO disclosed
EP-0447164-A1 Heterocyclic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1991-09-18 EP disclosed