Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261564 | 0.88 | NOTUM (0.57) | NOTUMHTR2AHTR2CPOLBGSTP1 | |
| SCHEMBL9844699 | 0.84 | NOTUM (0.53) | NOTUMKDM4ECA12ALDH1A1CA1 | |
| SCHEMBL9259282 | 0.79 | NOTUM (0.62) | NOTUMPOLBKDM4ECA12ALDH1A1 | |
| SCHEMBL9287309 | 0.78 | NOTUM (0.51) | NOTUMPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL2021908 | 0.76 | NOTUM (0.55) | NOTUMCA2GSTP1CA12ALDH1A1 | |
| SCHEMBL9844700 | 0.76 | NOTUM (0.62) | NOTUMHTR2AHTR2CHSD17B10CYP2A6 | |
| SCHEMBL9735956 | 0.76 | NOTUM (0.62) | NOTUMHTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL9736291 | 0.75 | NOTUM (0.57) | NOTUMKDM4EALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL9259627 | 0.73 | NOTUM (1.00) | NOTUMHTR2AHTR2CKDM4ECA12 | |
| SCHEMBL5774338 | 0.71 | NOTUM (0.41) | NOTUMPOLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |