Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 4/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844700 | 0.79 | NOTUM (0.62) | NOTUMHTR2AHTR2CSRD5A1DAO | |
| SCHEMBL17907965 | 0.77 | HTR2A (0.48) | NOTUMHTR2AHTR2CKMT2ATDP2 | |
| SCHEMBL9259627 | 0.77 | NOTUM (1.00) | NOTUMHTR2AHTR2CKMT2AALDH1A1 | |
| SCHEMBL30615209 | 0.77 | NOTUM (1.00) | NOTUMHTR2AHTR2CKMT2AALDH1A1 | |
| SCHEMBL9264812 | 0.76 | NOTUM (0.57) | NOTUMHTR2AHTR2CALDH1A1CYP19A1 | |
| SCHEMBL9736291 | 0.76 | NOTUM (0.57) | NOTUMSRD5A1ALDH1A1DAOKDM4E | |
| SCHEMBL9844699 | 0.72 | NOTUM (0.53) | NOTUMKMT2AALDH1A1MAT2AKDM4E | |
| SCHEMBL9844702 | 0.69 | NOTUM (0.62) | NOTUMSRD5A1ALDH1A1DAOKDM4E | |
| SCHEMBL30684248 | 0.68 | NOTUM (0.47) | NOTUM | |
| SCHEMBL17907930 | 0.67 | HTR2A (0.48) | NOTUMHTR2AHTR2CKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |