Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844702 | 0.86 | NOTUM (0.62) | NOTUMHSD17B10L3MBTL1TSHRCYP1A2 | |
| SCHEMBL9844700 | 0.79 | NOTUM (0.62) | NOTUMHSD17B10CYP1A2CYP2A6SRD5A1 | |
| SCHEMBL9735956 | 0.79 | NOTUM (0.62) | NOTUMHSD17B10MAPTSRD5A1CYP19A1 | |
| SCHEMBL9264812 | 0.79 | NOTUM (0.57) | NOTUMHSD17B10CYP1A2CYP2A6MAPT | |
| SCHEMBL9736291 | 0.79 | NOTUM (0.57) | NOTUML3MBTL1CYP1A2CYP2A6MAPT | |
| SCHEMBL30615209 | 0.77 | NOTUM (1.00) | NOTUMTSHRMAPTDAOALDH1A1 | |
| SCHEMBL9259627 | 0.77 | NOTUM (1.00) | NOTUMTSHRMAPTDAOALDH1A1 | |
| SCHEMBL9844699 | 0.75 | NOTUM (0.53) | NOTUMHSD17B10TSHRCYP1A2MAPT | |
| SCHEMBL24329594 | 0.70 | SMN1; SMN2 (0.44) | NOTUMHSD17B10L3MBTL1TSHRMAPT | |
| SCHEMBL9261564 | 0.69 | NOTUM (0.57) | NOTUMHSD17B10L3MBTL1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |